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. 2013 Apr 10;304(12):R1096–R1106. doi: 10.1152/ajpregu.00367.2012

Fig. 3.

Fig. 3.

ANG II infusion enhances baseline and NMDA-mediated reactive oxygen species (ROS) production in PVN cells. A: representative DHE images of ROS-dependent fluorescence induced by NMDA (100 μmol/l) in PVN cells from ANG II-recipient mice. Scale bar = 20 μm. B: baseline ROS production in PVN cells from saline and ANG II-recipient mice is shown. **P < 0.01 vs. saline. C: NMDA increased ROS dose-dependently in isolated PVN cells of saline-infused mice, an effect abolished by MK 801 (10 μmol/l) or gp-91ds-tat (1 μmol/l). NMDA-mediated ROS production is enhanced in PVN cells of mice receiving ANG II infusion. **P < 0.01 vs. vehicle; #P < 0.05 vs. vehicle or saline-infusion; ##P < 0.01 vs. vehicle or saline-infusion using ANOVA and Tukey's test. D: effect of NMDA on the time course of ROS-dependent fluorescence assessed by DHE in PVN cells from saline and ANG II-infused mice. *P < 0.05 using unpaired t-test.