Fig. 6.
CA1 pyramidal neuron frequency/current (f/I) curves exhibit type 1 excitability. A: time course of interspike intervals (ISIs) during applied depolarizing current steps (Iapp) in a single neuron. Adaptation is evident at higher frequencies. B: the f/I curves for 13 CA1 pyramidal neurons have spiking onset at low frequency at the rheobase. Each symbol represents a different neuron and was calculated as the average of the data points measured after 2 s (vertical, dashed line in A). Ithres, current threshold.