Fig. 3.

Chronic effects of TNF-α pretreatment on the apneic responses to Cap and PBG. Measurements were made in 3 different groups of mice, n = 6 in each group: 1) Veh: 1–2 days after intratracheal instillation of vehicle (PBS, 0.03 ml); 2) and 3): 1–2 days and 6–7 days after intratracheal instillation of TNF-α (10 μg/ml, 0.03 ml), respectively. Data are means ± SE. *Significantly different from the corresponding response in mice pretreated with vehicle; +significantly different from the corresponding response in mice at 1–2 days after TNF-α pretreatment; #significantly different from the lowest dose in the same group.