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. 2013 Mar 14;114(11):1603–1609. doi: 10.1152/japplphysiol.01283.2012

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Fig. 5. — Model of interactions between CapZ and sarcomeric actin. A: in unstrained conditions when NRVMs beat spontaneously but are not growing, the CapZ tightly caps the barbed end of the actin filament [on rate (light gray arrow) > off rate (dark gray arrow)]. B: the deletion of β tentacle significantly increases CapZ dynamics [off rate (light gray arrow) > on rate (dark gray arrow)], which weakens the binding of CapZ to the actin filament. The dynamics of the actin monomer on and off the actin filament is elevated (arrows with two directions). C: mechanical stimulation also significantly increases CapZ dynamics [off rate (light gray arrow) > on rate (dark gray arrow)], possibly because of structural change of the β tentacle (black arrow) through posttranslational modification. The β tentacle of CapZ is released from its actin-binding state, which leads to an elevated actin off rate (arrows with two directions).