Table 2. One-, five- and ten-year survival rates and unadjusted hazard ratios and 95% confidence intervals by demographic and clinical predictor factors for ALL cases only (N=823).
| Variable | One-year survival (% (95% CI)) | Five-year survival (%) | Ten-year survival (%) | Hazard ratio (95% CI) | P-value |
|---|---|---|---|---|---|
|
Sex | |||||
| Female | 86 (82–90) | 66 (61–71) | 63 (57–68) | 1.00 | |
| Male |
85 (82–88) |
62 (58–66) |
58 (53–62) |
1.20 (0.96–1.49) |
0.11 |
|
Age group (years) | |||||
| 0–1 | 73 (63–81) | 47 (36–57) | 44 (34–54) | 1.00 | |
| 2–4 | 88 (85–91) | 69 (64–74) | 66 (61–71) | 0.47 (0.34–0.65) | <0.0001 |
| 5–9 | 90 (85–93) | 70 (63–75) | 63 (57–70) | 0.53 (0.38–0.75) | <0.0001 |
| 10–14 |
80 (73–86) |
53 (45–61) |
49 (41–57) |
0.82 (90.57–1.17) |
0.27 |
|
Calendar period | |||||
| 1968–1977 | 67 (60–73) | 31 (25–37) | 27 (21–33) | 1.00 | |
| 1978–1987 | 87 (81–91) | 62 (54–68) | 59 (52–66) | 0.38 (0.29–0.50) | <0.0001 |
| 1988–1997 | 94 (89–96) | 78 (71–83) | 71 (64–76) | 0.21 (0.16–0.28) | <0.0001 |
| 1997–2010 |
96 (92–98) |
88 (82–92) |
87 (81–91) |
0.11 (0.07–0.17) |
<0.0001 |
|
Trial period for ALL aged 1–14 years | |||||
| Before UKALL V (January 1968–December 1975) | 56 (48–63) | 19 (14–25) | 16 (11–22) | 1.00 | |
| UKALL V, VI, VII (January 1976–August 1980) | 70 (60–78) | 43 (33–52) | 40 (30–49) | 0.49 (0.37–0.66) | <0.0001 |
| UKALL VIII (September 1980–December 1984) | 86 (76–92) | 63 (52–72) | 60 (48–69) | 0.27 (0.18–0.38) | <0.0001 |
| UKALL X (January 1985–September 1990) | 92 (85–95) | 76 (67–83) | 72 (63–79) | 0.17 (0.12–0.25) | <0.0001 |
| UKALL XI (October 1990–February 1997) | 95 (90–98) | 80 (72–85) | 72 (64–79) | 0.17 (0.12–0.23) | <0.0001 |
| ALL 97 (March 1997–November 2002) | 94 (88–97) | 85 (76–90) | 84 (77–90) | 0.09 (0.06–0.14) | <0.0001 |
| ALL 2003 (October 2003–December 2010) |
98 (93–100) |
92 (85–96) |
— |
0.05 (0.02–0.10) |
<0.0001 |
|
Paternal social class | |||||
| I/II | 90 (84–94) | 75 (68–81) | 72 (64–78) | 1.00 | |
| IIIN/M | 83 (79–86) | 59 (54–63) | 56 (51–61) | 1.73 (1.25–2.40) | 0.001 |
| IV/V |
86 (79–91) |
62 (53–69) |
56 (48–64) |
1.60 (1.09–2.34) |
0.02 |
|
White blood cell count | |||||
| 0–50 000 | 97 (89–99) | 90 (79–95) | 85 (73–92) | 1.00 | |
| >50 000 | 83 (80–86) | 59 (55–63) | 55 (51–59) | 4.26 (2.19–8.28) | <0.0001 |
Abbreviations: ALL=acute lymphoblastic leukaemia; CI=confidence interval.