Table 3. Association between genetic polymorphisms of UGTs and bladder cancer risk.

			Genotype			MAF	Model
SNP	Region	Case/Control	WW	WV	VV		Model	OR (95% CI)a	P-value
rs7571337	Chr2:234231157	Case	215	336	163	0.46	Dom	0.71 (0.56–0.90)	0.005
		Control	189	391	203	0.51	Rec	0.84 (0.66–1.08)	0.169
							Add	0.82 (0.71–0.95)	0.009
rs17864684	Chr2:234244102	Case	534	165	19	0.14	Dom	0.72 (0.57–0.90)	0.005
		Control	529	227	27	0.18	Rec	0.81 (0.44–1.49)	0.496
							Add	0.76 (0.62–0.93)	0.009
rs4233633	Chr2:234284676	Case	581	123	14	0.11	Dom	0.72 (0.55–0.93)	0.012
		Control	598	177	6	0.12	Rec	0.42 (0.91–6.46)	0.077
							Add	0.80 (0.63–1.02)	0.068
rs2736520	Chr4:70370761	Case	511	189	18	0.16	Dom	1.36 (1.07–1.73)	0.012
		Control	593	171	19	0.13	Rec	1.09 (0.55–2.13)	0.812
							Add	1.27(1.03–1.57)	0.023
rs3822179	Chr4:70390784	Case	614	98	6	0.08	Dom	0.70 (0.53–0.93)	0.015
		Control	633	139	11	0.10	Rec	0.68 (0.24–1.91)	0.461
							Add	0.73 (0.56–0.94)	0.016
rs4148326	Chr2:234338201	Case	205	358	155	0.47	Dom	1.33 (1.06–1.67)	0.015
		Control	270	361	152	0.42	Rec	1.11 (0.86–1.44)	0.426
							Add	1.17 (1.01–1.35	0.041
rs1604144	Chr2:234270574	Case	390	276	52	0.26	Dom	0.77 (0.63–0.96)	0.017
		Control	386	324	73	0.30	Rec	0.77 (0.52–1.13)	0.177
							Add	0.82 (0.69–0.96)	0.015
rs17868322	Chr2:234245233	Case	653	63	2	0.05	Dom	1.63 (1.09–2.44)	0.019
		Control	734	44	2	0.03	Rec	0.89 (0.12–6.74)	0.906
							Add	1.55 (1.05–2.28)	0.027
rs2602374	Chr2:234233703	Case	357	288	73	0.30	Dom	1.07 (0.87–1.32)	0.527
		Control	408	319	56	0.28	Rec	1.57 (1.07–2.29)	0.020
							Add	1.13 (0.96–1.34)	0.131
rs17854828	Chr2:234210600	Case	543	157	18	0.13	Dom	0.76 (0.60–0.96)	0.022
		Control	553	205	25	0.16	Rec	0.84 (0.45–1.57)	0.583
							Add	0.80 (0.65–0.98)	0.032
rs4148328	Chr2:234342398	Case	307	317	94	0.35	Dom	0.84 (0.67–1.03)	0.100
		Control	299	361	123	0.39	Rec	0.71 (0.52–0.96)	0.028
							Add	0.84 (0.72–0.98)	0.023
rs2741042	Chr2:234230656	Case	337	297	84	0.32	Dom	1.12 (0.91–1.38)	0.286
		Control	396	320	67	0.29	Rec	1.49 (1.05–2.12)	0.026
							Add	1.16 (0.99–1.36)	0.069
rs1113193	Chr2:234233876	Case	413	259	45	0.24	Dom	0.79 (0.64–0.98)	0.028
		Control	410	319	54	0.27	Rec	0.94 (0.61–1.43)	0.764
							Add	0.85 (0.72–1.01)	0.060
rs1104892	Chr2:234285011	Case	179	369	169	0.49	Dom	1.30 (1.03–1.64)	0.030
		Control	241	375	167	0.45	Rec	1.12 (0.87–1.44)	0.395
							Add	1.15 (0.99–1.34)	0.061
rs2741044	Chr2:234244107	Case	338	293	75	0.31	Dom	1.15 (0.93–1.43)	0.189
		Control	403	310	60	0.28	Rec	1.49 (1.03–2.16)	0.034
							Add	1.18 (1.00–1.38)	0.051
rs2741045	Chr2:234244879	Case	337	306	75	0.32	Dom	1.16 (0.94–1.43)	0.163
		Control	403	320	60	0.28	Rec	1.49 (1.03–2.15)	0.036
							Add	1.18 (1.00–1.39)	0.045
rs1105880	Chr2:234266704	Case	292	327	99	0.37	Dom	1.19 (0.96–1.48)	0.106
		Control	356	342	85	0.33	Rec	1.36 (0.98–1.87)	0.064
							Add	1.18 (1.01–1.38)	0.037
rs6759892	Chr2:234266408	Case	233	342	143	0.44	Dom	1.20 (0.96–1.50)	0.106
		Control	289	369	125	0.40	Rec	1.29 (0.98–1.70)	0.070
							Add	1.17 (1.01–1.36)	0.038

Abbreviations: Add=additive model; CI=confidence interval; Dom=dominant model; MAF=minor allele frequency; OR=odds ratio; Rec=recessive model; SNP=single-nucleotide polymorphism; UGT=UDP-glucuronosyltransferases; VV=homozygous variant genotype; WV=heterozygous genotype; WW=wild-type genotype.

^aAdjusting for age, sex, ethnicity, and smoking.