Table 1. Percentage and relative risks for initiators affecting the transition rate from free-of-breast cancer to the pre-clinical screen-detectable phase (PCDP).
| Variables | Percentage (%) | Relative risk of being breast cancer in the PCDP (pre-symptomatic cases) | References |
|---|---|---|---|
|
Gene mutation | |||
| BRCA1 gene mutation | 0.11 | 20.26 | Peto et al, 1999; Chen and Parmigiani, 2007 |
|
BRCA2 gene mutation |
0.12 |
15.44 |
|
|
Breast density (BI-RADS) | |||
| Almost entirely fat | 0.92 | 1.00 | del Carmen et al, 2007; Cumming et al, 2009 |
| Scattered fibroglandular densities | 15.86 | 2.03 | |
| Heterogeneously dense | 56.09 | 2.95 | |
| Extremely dense |
27.13 |
4.03 |
|
|
Polygenes (dbSNP no.) per allele | |||
| rs2981582 | 38 | 1.26 | Easton et al, 2007; Hunter et al, 2007 |
| rs3803662 | 25 | 1.20 | Easton et al, 2007 |
| rs889312 | 28 | 1.13 | Easton et al, 2007 |
| rs3817198 | 30 | 1.07 | Easton et al, 2007 |
| rs13281615 | 40 | 1.08 | Stacey et al, 2007 |
| rs13387042 | 50 | 1.20 | Cox et al, 2007 |
| rs1045485 |
86 |
1.13 |
Easton et al, 2007 |
|
BMI (kg m−2) | |||
| ⩽23 | 37.11 | 1.00 | Chen et al, 2004 |
| >23 |
62.89 |
2.59 |
Hsieh et al, 2002 |
|
Age at first full-term pregnancy (years) | |||
| ⩽25 | 66.53 | 1.00 | Chen et al, 2004 |
| >25 | 33.47 | 1.99 | Hsieh et al, 2002 |