Table 2. Relative risks of death from disease and overall death within 5 years according to clinicopathological factors and PODXL expression in Cohort I and Cohort II.
| Cohort I | Cohort II | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Risk of death within 5 years |
Risk of death from disease |
Risk of death within 5 years |
|||||||
|
Univariable |
Multivariable |
Univariable |
Multivariable |
Univariable |
Multivariable |
||||
| n (Events) | HR (95% CI) | HR (95% CI) | n (Events) | HR (95% CI) | HR (95% CI) | n (Events) | HR (95% CI) | HR (95% CI) | |
|
Age | |||||||||
| Continuous |
100 (47) |
1.05 (1.02–1.08) |
1.05 (1.02–1.09) |
300 (101) |
1.04 (1.02–1.07) |
1.05 (1.03–1.07) |
343 (170) |
1.06 (1.05–1.08) |
1.07 (1.05–1.09) |
|
Gender | |||||||||
| Female | 26 (12) | 1.00 | 1.00 | 72 (28) | 1.00 | 1.00 | 83 (40) | 1.00 | 1.00 |
| Male |
74 (35) |
0.93 (0.48–1.79) |
1.29 (0.61–2.72) |
228 (73) |
0.80 (0.52–1.24) |
1.00 (0.64–1.56) |
260 (130) |
0.97 (0.68–1.39) |
1.22 (0.85–1.76) |
|
Stage | |||||||||
| Ta | 40 (7) | 1.00 | 1.00 | 104 (13) | 1.00 | 1.00 | 115 (35) | 1.00 | 1.00 |
| T1 | 23 (16) | 5.08 (2.08–12.40) | 1.86 (0.71–6.00) | 97 (25) | 2.20 (1.13–4.31) | 2.15 (1.10–4.22) | 115 (52) | 1.62 (1.05–2.48) | 1.57 (1.02–2.41) |
| T2–4 |
37 (24) |
6.01 (2.58–14.00) |
2.36 (0.74–7.57) |
99 (63) |
8.93 (4.90–16.27) |
7.56 (4.09–13.97) |
113 (83) |
4.35 (2.92–6.48) |
3.88 (2.57–5.86) |
|
Grade | |||||||||
| Low | 43 (9) | 1.00 | 1.00 | 75 (7) | 1.00 | 1.00 | 82 (20) | 1.00 | 1.00 |
| High |
57 (38) |
4.64 (2.24–9.64) |
3.61 (1.73–7.56) |
225 (94) |
5.79 (2.68–12.49) |
1.53 (0.59–3.94) |
261 (150) |
3.10 (1.94–4.95) |
1.20 (0.68–2.12) |
|
PODXL expression | |||||||||
| Negative | 79 (33) | 1.00 | 1.00 | 269 (80) | 1.00 | 1.00 | 308 (144) | 1.00 | 1.00 |
| Positive | 21 (14) | 2.25 (1.20–4.22) | 2.05 (1.06–3.94) | 31 (21) | 4.36 (2.67–7.10) | 2.70 (1.60–4.55) | 35 (26) | 3.10 (2.03–4.72) | 2.18 (1.39–3.41) |
Abbreviations: CI=confidence interval; HR=hazards ratio; PODXL=podocalyxin-like.