Table 1.

Toll-like receptor single nucleotide polymorphisms significantly associated with allergic diseases including allergic rhinitis from different populations

TLR	Ethnic group	Design (sample size)	Age (years)	rs	Allele	Minor allele frequency (%)	Allergic diseases
							Inheritance	Allergic rhinitis	Others
TLR1	German37	Case-control (cases: 624, controls: 1,248)	9–11	rs4833095	C/T	19	Dominant		Atopic asthma
				rs5743595	T/C	17	Dominant		Atopic asthma
TLR2	German40	Cross-sectional (n = 3099)	9–11	rs5743708	G/A	3	Dominant		Atopy
	German/Austrian41	Cross-sectional (n = 609)	6–13	rs4696480	A/T	49.7	Dominant	Yesa	Atopya; asthmaa
	Korean38	Case-control (cases: 440, control: 528)	adults	rs3804099	T/C	Cases: 32 Controls: 31	Haplotype (C-C)	Yes	Atopic asthma
				rs3804100	T/C	Cases: 31 Controls: 29
	Norwegian39	Case-control (cases: 108, controls: 496)	children	rs3804100	T/C	Cases: 8 Controls: 11	Dominant		Atopic asthma
TLR4	Canadian42	Cross-sectional (n = 915)	adults	rs4986790	A/G	5	Dominant	Yes	Atopyb
				rs4986791	C/T	4.7
	Turkish43	Cross-sectional (n = 613)	6–18	rs4986790	A/G	5.1	Dominant		Atopic asthma
				rs4986791	C/T	5.1	Dominant
	Swedish44	Cross-sectional (n = 115)	8–14	rs4986790	A/G	9.6	Dominant		Atopic asthma
TLR6	German37	Case-control (cases: 624, controls:1248)	9–11	rs5743789	T/A	18	Dominant		Atopic asthma
				rs5743810	C/T	40	Dominant		Atopic asthma
	German45	Case-control (cases: 132, controls: 212)	2–15 22–87	rs5743810	C/T	Cases: 49 Controls: 40	Dominant		Atopic asthma
	Chinese46	Case-control (cases: 318; controls: 352)	16–74	rs2381289	C/T	Cases: 48 Controls: 41	Dominant	Yesd
TLR7	Danish47	Cross-sectional (Samples A: 135, B: 100 families)	15–45	rs179008	A/T	Sample A: 24 Sample B: 21	Recessive and additive	Yese	Atopyb
TLR8	Danish47	Cross-sectional (Samples A: 135, B: 100 families)	15–45	rs2407992	G/C	Sample A: 42 Sample B: 38	Recessive and additive	Yese	Atopyb; dermatitisb
				rs5741883	C/T	Sample A: 25 Sample B: 20	Recessive	Yesc
TLR9	German48	Cross-sectional and case-control (n = 483, cases: 274, controls: 252)	trios	rs5743836	T/C	Cases: 13 Controls: 11	TDT		Atopic eczema
TLR10	German37	Case-control (cases: 624, controls: 1248)	9–11	rs4129009	A/G	16	Dominant		Atopic asthma
	Chinese46	Case-control (cases: 318, controls: 352)	16–74	rs11466651	G/A	Cases: 7 Controls: 9	Dominant	Yesd

Notes:

^aAmong farmers’ children;

^bAmong females;

^cAmong girls in sample A;

^dAmong asthmatic patients;

^eSample A + sample B.

Abbreviation: TDT, transmission disequilibrium test.