Table 3.

Summary of monogenic forms of Parkinson’s disease (PD)

Name	Disease	Inheritance	Chromosome	Protein	Function
PARK1	Familial PD	Autosomal dominant	4q21-q22	α-synuclein	Synaptic protein
PARK2	Young-onset PD	Autosomal recessive	6q25.2-q27	Parkin	Ubiquitin-protein ligase
PARK4	Familial PD	Autosomal dominant	4q region	α-synuclein duplication or triplications	Synaptic protein
PARK5	Familial PD	Autosomal recessive	4p15	Ubiquitin carboxy-terminal hydrolase	Hydrolase of ubiquitin
PARK6	Young-onset PD	Autosomal recessive	1p35-p36	PINK-1	Mitochondrial anti-stress-induced degeneration
PARK7	Young-onset PD	Autosomal recessive	1p36	DJ-1	Sumolyation pathway
PARK8	Familial PD	Autosomal dominant	12p11.2-q13.1	LRRK2	Protein phosphorylation
GBA	Familial PD	Autosomal dominant	1q21	Gluco-cerebrosidase	Membrane lipid