Figure 8. FoxO6 and PGC-1α form a regulatory loop.

PGC-1α is recruited by unknown transcription factors to co-activate FoxO6 promoter activity, but FoxO6 directly binds to PGC-1α promoter to repress its activity. However, both events can be ameliorated by exercise that further induces PGC-1α expression to promote oxidative metabolism. Dashed lines indicate movement of transcription factors.