Figure 8.

Human lung stem cells regenerate the injured mouse lung. Photomicrographs demonstrating engraftment of human lung c-kit-positive cells into the cryo-injured mouse lung. These cells, which express green fluorescent protein (EGFP), regenerated the injured area of lung tissue. The c-kit-positive cells differentiated into lung epithelial cells (area 1), and formed lung bronchioles as evidenced by staining for Clara cell 10-kDa secretory protein (CC-10), alveolar lung tissue (area 2) as evidenced by staining for aquaporin-5 (AQP5), and pulmonary arterioles (area 3) as evidenced by staining for von-Willebrand factor (VWF). Reproduced with permission from [99].