Table 1.
Metabolites from plasma samples of healthy and polymicrobial infected mice
| Metabolite | Healthy controls | 6 hours post sepsis | 24 hours post sepsis |
|---|---|---|---|
| Arginine (μM) | 101.97 ± 8.12 | 78.25 ± 5.10 | 43.65 ± 10.06†‡ |
| Proline (μM) | 65.00 ± 4.98 | 34.79 ± 3.89† | 29.99 ± 5.18† |
| Ornithine (μM) | 55.84 ± 3.41 | 30.04 ± 3.63† | 28.31 ± 4.64† |
| Putrescine (μM) | 0.40 ± 0.03 | 0.19 ± 0.06 | 4.51 ± 1.81*‡ |
| Urea (mg/dl) | 28.08 ± 1.57 | 36.42 ± 2.09 | 55.61 ± 7.05*‡ |
| Glutamine (μM) | 590.40 ± 118.91 | 635.30 ± 107.15 | 548.50 ± 105.21 |
| Citrulline (μM) | 47.67 ± 3.56 | 45.79 ± 7.18 | 50.16 ± 4.96 |
| Acetylornithine (μM) | 2.48 ± 0.15 | 2.65 ± 0.33 | 2.08 ± 0.12 |
| Glutamic acid (μM) | 18.68 ± 3.33 | 14.04 ± 4.30 | 34.38 ± 11.64 |
| Spermidine (μM) | 0.49 ± 0.02 | 0.43 ± 0.06 | 0.08 ± 0.05†‡ |
Data presented as mean ± standard error of the mean. Investigated metabolites from plasma samples of healthy controls (n = 10) and of polymicrobial infected mice 6 hours (n = 10) and 24 hours (n = 10) post sepsis induction. Statistical analysis by one-way analysis of variance (ANOVA) and post-hoc tests using the Scheffé procedure. *Statistically significant difference compared with healthy controls (P ≤ 0.05; ANOVA). †Statistically significant difference compared with healthy controls (P ≤ 0.001; ANOVA). ‡Statistically significant difference between 6 hours and 24 hours post sepsis induction (P ≤ 0.05; ANOVA). Significant data are indicated in bold.