Table 6.

Summary of clinical trials on intra-arrest hypothermia (IATH) during cardiac arrest

	Setting	Method	Pts	CTRL	VF/VT (%)	Δt at admission	Δt vs CTRL	ROSC	Hospital admission	Survival all patients	Survival admitted pts
Callaway [19]	OHCA	Cranial cooling	22	Y (NT)	41	-0.02°C/min	NS	IATH 33% CTRL 0%	IATH 66% CTRL 15%	IATH 0% CTRL 0%	IATH 0% CTRL 0%
Bruel [15]	OHCA	Cold iv fluids	33	N	24	- 2.1°C	NA	61%	61%	12%	20%
Kämärainen [20]	OHCA	Cold iv fluids	17	N	59	-1.34°C	NA	71%	64%	6%	9%
Castrén [16]	OHCA	Trans-nasal	194	Y (PATH)	30	-1.3°C (tymp)	-0.7°C (core) - 1.3°C (tymp)	IATH 38% CTRL 43%	IATH 36% CTRL 42%	IATH 15% CTRL 13%	IATH 44% CTRL 31%
Garrett [18]	OHCA	Cold iv fluids	542	Y (NT)	22	NA	NA	IATH 37% CTRL 27%	IATH 28% CTRL 23%	IATH 13% CTRL 12%	IATH 44% CTRL 51%

Δt, difference in temperature; CTRL, control group; iv, intravenous; NA, not applicable/available; N, no; NS, not significant; NT, normothermia; OHCA, out-of-hospital cardiac arrest; PATH, conventional (post-arrest) hypothermia; Pts., patients; ROSC, return of spontaneous circulation; tymp, tympanic; VF, ventricular fibrillation; VT, ventricular tachycardia; Y, yes