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. 2012 Apr 5;16(2):R55. doi: 10.1186/cc11298

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Copyright ©2012 Liu and Chintagari; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of γ-aminobutyric acid (GABA) on alveolar fluid clearance after ventilator-induced lung injury. Adult female rats were subjected to high-tidal-volume (40 ml/kg BW) ventilation for 60 minutes with and without instillation of GABA (500 μM) and/or bicuculline (200 μM). A 5% bovine serum albumin along with 1 mg/ml FITC-albumin was included in the instillate for estimating alveolar fluid clearance. A decrease in FITC-albumin concentration was then calculated. Shown are the results of the percentage decrease in FITC-albumin concentration after ventilation for 1 hour. Shown are the mean ± SEM (n = 4 to 5 per group). *P < 0.05 versus saline.