. Author manuscript; available in PMC: 2013 Jun 13.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Jul 21;21(18):5239–5243. doi: 10.1016/j.bmcl.2011.07.043

Table 2.

SAR study for the piperazine region^*

Entry	Compd	1% O₂ IC₅₀ (uM)
1	1	0.43
2	11	0.47
3	12	1.7
4	13	9.4
5	14	0.81
6	15	27.5
7	39	27.6
8	16	0.09
9	17	0.16
10	18	27.6
11	19	inactive

Values of IC₅₀ are the mean of three independent experiments.