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. Author manuscript; available in PMC: 2013 Jun 13.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jul 21;21(18):5239–5243. doi: 10.1016/j.bmcl.2011.07.043

Table 3.

SAR study for R2 position*

Scaffold Entry Comp Scaffold R2 1% O2 IC50 (uM)
1 20 A 4-F inactive
2 21 A 2-tBu inactive
3 22 A 2-NO2 inactive
graphic file with name nihms313590t15.jpg 4 1 A 2-EtO 0.43
5 23 A H inactive
6 24 A 2-Cl inactive
7 25 A 2-Me inactive
8 26 A 2-Benzyloxy inactive
9 27 A 2-F inactive
10 28 A 2-PhO inactive
graphic file with name nihms313590t16.jpg 11 29 A 2-MeO 3.3
12 30 A 2-CF3 inactive
13 31 B 2-MeO, 5-CF3 0.2
14 32 B 2-MeO, 5-NO2 4.2
15 42 B 2-EtNH 4.1
16 33 B 2-Benzyloxy 22.9
17 34 B 2-isobutoxy 6.2
18 35 B 2-EtS 3.5
19 36 B 4-MeO inactive
20 16 B 2-EtO 0.09
*

Values of IC50 are the mean of three independent experiments.