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(A) Sox7 could reduce Wnt-1 induce TOPFLASH luciferase activity dose dependently in HEK293 cells. FOPFLASH luciferase activity was used as a negative control. (B) Transient transfection of Flag/Sox could remarkably reduce the expressions of C-myc and cyclinD1 in HEC1A (wild-type β-catenin) and TOV112D (mutant β-catenin) cells.
