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. 2012 Dec 30;3(12):1688–1699. doi: 10.18632/oncotarget.791

Figure 4. SkE induces cell death of tumors exhibiting the BRAF V600E mutation.

Figure 4

(A) PLX-sensitive and PLX-resistant 451Lu melanoma cell lines were treated with either 2 μM PLX or increasing doses of SkE. Forty-eight hours later, cell metabolism was measured by the XTT assay as described in the Materials and Methods section. (B) Primary blood cells from patients suffering from hairy cell leukemia were treated with 2 μM PLX, 10 μM U0126 or increasing doses of SkE. Twenty-four hours later, cells were stained using propidium iodide, and cell death was analyzed with a cytometer.