Table 5.
Associations of height with incident AF before and after adjustment for potentially mediating factors
| HR per SD height | CI | P-value | |
|---|---|---|---|
| Women | |||
| Base model | 1.21 | 1.12–1.33 | <0.001 |
| +LA diametera | 1.19 | 1.10–1.30 | <0.001 |
| +LV massa | 1.18 | 1.08–1.29 | <0.001 |
| +LV diastolic dimensiona | 1.21 | 1.11–1.33 | <0.001 |
| +SBP or history of treated hypertension | 1.24 | 1.13–1.35 | <0.001 |
| +Peak E velocity (m/s)a | 1.22 | 1.12–1.33 | <0.001 |
| +Peak A velocity (m/s)a | 1.22 | 1.12–1.33 | <0.001 |
| Combined above (excluding NT-proBNP) | 1.20 | 1.10–1.31 | <0.001 |
| Base model (NT-proBNP available) | 1.23 | 1.12–1.36 | <0.001 |
| + NT-proBNP | 1.23 | 1.12–1.36 | <0.001 |
| Combined (including NT-proBNP) | 1.20 | 1.09–1.33 | <0.001 |
| Men | |||
| Base model | 1.17 | 1.07–1.28 | <0.001 |
| +LA diametera | 1.16 | 1.06–1.27 | 0.002 |
| +LV massa | 1.14 | 1.04–1.25 | 0.005 |
| +LV diastolic dimensiona | 1.15 | 1.05–1.26 | 0.003 |
| +SBP or history of treated hypertension | 1.20 | 1.10–1.32 | <0.001 |
| +Peak E velocity (m/s)a | 1.18 | 1.07–1.29 | <0.001 |
| +Peak A velocity (m/s)a | 1.17 | 1.07–1.28 | <0.001 |
| Combined above (excluding NT-proBNP) | 1.16 | 1.06–1.27 | 0.002 |
| Base model (NT-proBNP available) | 1.24 | 1.11–1.38 | <0.001 |
| +NT-proBNP | 1.27 | 1.14–1.41 | <0.001 |
| Combined (including NT-proBNP) | 1.26 | 1.13–1.42 | <0.001 |
All models adjusted for BMI, clinic site, race, and education; stratified by age.
LA, diameter measured in cm; LV, mass measured in g; LV, diastolic dimension measured in cm; SBP, measured in mmHg, and NT-proBNP measured in pg/dL. All HR are reported per unit of measurement. n for total population = 4480. n for NT-proBNP studies = 3464.
aQuantiles of Peak E velocity, Peak A velocity, LA diameter, LV mass, LV diastolic dimension, PR interval used due to non-linearity; BNP and BNP-squared included due to non-linear effects.