Effects of the Se-biofortified porcine serum (Se-Na) treatment on the quadrantal diagrams (A,B), apoptotic rate (C), and relative mRNA abundance of Bcl-2, p53, p38, and Caspase3 (D) of the human small cell lung cancer cells (NCI-H446) in Expt. 1. The early and late apoptotic cells are located in the lower right and upper right quadrants of A and B, respectively. In all panels, the control porcine serum was supplemented with sodium selenite to match the Se concentration with that of Se-Na. Data in C and D are means ± SEs, n = 4. *Different from control, P < 0.05. Bcl-2, B-cell lymphoma 2; p38, mitogen-activated protein kinase p38; p53, tumor suppressor protein 53; Se-Na, serum from pigs fed 3.0 mg Se/kg in Expt. 1.