Table 1.
Association of MRAS variants with coronary artery disease
|
Model |
Unstandardized coefficient |
Standardized coefficient |
t |
p value |
95.0% C.I. for beta |
||
|---|---|---|---|---|---|---|---|
| Beta | S.E. | Beta | Lower bound | Upper bound | |||
| Sex |
−0.107 |
0.009 |
−0.102 |
−12.05 |
0.000*** |
−0.125 |
−0.09 |
| Age |
0.003 |
0.000 |
0.081 |
8.53 |
0.000*** |
0.002 |
0.003 |
| FH |
−0.004 |
0.01 |
−0.003 |
−0.401 |
0.689 |
−0.024 |
0.016 |
| T2DM |
0.082 |
0.009 |
0.082 |
9.034 |
0.000*** |
0.064 |
0.1 |
| MI |
0.586 |
0.01 |
0.56 |
59.874 |
0.000*** |
0.567 |
0.605 |
| HTN |
0.03 |
0.01 |
0.026 |
2.907 |
0.004*** |
0.01 |
0.05 |
| OBS |
−0.018 |
0.008 |
−0.018 |
−2.177 |
0.03* |
−0.035 |
−0.002 |
| rs119338_C |
0.002 |
0.023 |
0.002 |
0.106 |
0.915 |
−0.043 |
0.048 |
| rs166195_C |
0.053 |
0.049 |
0.045 |
1.076 |
0.282 |
−0.044 |
0.15 |
| rs166195_T |
0.038 |
0.048 |
0.033 |
0.785 |
0.433 |
−0.057 |
0.133 |
| rs253662_T |
−0.012 |
0.019 |
−0.009 |
−0.622 |
0.534 |
−0.049 |
0.026 |
| rs1720819_T |
−0.182 |
0.052 |
−0.119 |
−3.505 |
0.000*** |
−0.284 |
−0.08 |
| rs1720819_G |
−0.164 |
0.055 |
−0.104 |
−2.996 |
0.003** |
−0.272 |
−0.057 |
| rs6782181_AA |
0.073 |
0.031 |
0.071 |
2.379 |
0.017* |
0.013 |
0.133 |
| rs6782181_T |
0.057 |
0.031 |
0.055 |
1.816 |
0.069 |
−0.005 |
0.118 |
| rs3732837_AA |
0.013 |
0.022 |
0.009 |
0.58 |
0.562 |
−0.03 |
0.056 |
| rs3732837_T |
−0.027 |
0.043 |
−0.017 |
−0.643 |
0.52 |
−0.111 |
0.056 |
| rs9818870_C |
0.097 |
0.04 |
0.063 |
2.416 |
0.016* |
0.018 |
0.176 |
| rs9818870_T | 0.14 | 0.054 | 0.087 | 2.612 | 0.009** | 0.035 | 0.246 |
The table shows the significant association of the MRAS gene variants with CAD following Bonferroni correction. Beta, odds ratio coefficient; FH family history of CAD, T2DM type 2 diabetes mellitus, MI myocardial infarction, HTN hypertension, OBS obesity, C.I confidence interval, S.E. standard error; t, standard t test. *p < 0.05; **p < 0.01; ***p < 0.005.