Table 2.
Association of MRAS gene with obesity and dyslipidaemia
| Variant | Controls | Cases |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|---|
| Exp( B ) (95% C.I.) | p value | Exp( B ) (95% C.I.) | p value | |||
| Obesity |
|
|
|
|
|
|
| rs6782181_GG |
0.153 |
0.397 |
1.15(1.02–1.29) |
0.023* |
1.16(1.03–1.30) |
0.017* |
| Hypercholesterolaemia |
|
|
|
|
|
|
| rs253662_TT |
0.051 |
0.038 |
0.73(0.59–0.90) |
0.041* |
0.74(0.53–1.01) |
0.054 |
| rs6782181_GG |
0.015 |
0.022 |
1.47(1.07–2.03) |
0.018* |
1.23(1.02–1.47) |
0.019* |
| Low HDL levels |
|
|
|
|
|
|
| rs166195_CT+TT |
0.356 |
0.385 |
1.14(1.00–1.29) |
0.047* |
1.00(0.99–1.00) |
0.961 |
| rs253662_CT+TT |
0.318 |
0.344 |
1.13(0.99–1.29) |
0.064 |
1.16(1.01–1.32) |
0.030* |
| rs6782181_GG |
0.151 |
0.167 |
1.13(1.00–1.27) |
0.045* |
1.15(1.02–1.30) |
0.023* |
| High LDL-cholesterol |
|
|
|
|
|
|
| rs253662_T |
0.192 |
0.162 |
0.82(0.70–0.96) |
0.013* |
0.82(0.69–0.96) |
0.014* |
| rs253662_CT+TT |
0.336 |
0.291 |
0.82(0.67–0.98) |
0.028* |
0.81(0.68–0.98) |
0.030* |
| rs6782181_G |
0.387 |
0.356 |
0.88(0.77–0.99) |
0.038* |
0.88(0.77–0.99) |
0.040* |
| rs6782181_AG+GG |
0.614 |
0.564 |
0.82(0.68–0.97 |
0.019* |
0.81(0.68–0.97) |
0.019* |
| Hypertriglyceridaemia |
|
|
|
|
|
|
| rs6782181_G | 0.152 | 0.175 | 1.19(1.00–1.42) | 0.067 | 1.29(1.01–1.45) | 0.043* |
The table shows the MRAS variants associated with the disease traits. B, odds ratio; C.I., confidence interval. *p < 0.05.