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. Author manuscript; available in PMC: 2013 Jun 13.
Published in final edited form as: Nat Chem Biol. 2010 Oct 3;6(11):829–836. doi: 10.1038/nchembio.453

Figure 5. Pyrvinium selectively decreases cell viability of colon cancer cells with activating mutations in the Wnt pathway.

Figure 5

(a–c) Cell viability assays. Cell viability was determined following treatment with pyrvinium pamoate for 72 h. Mean ± s.e.m. is shown (assays performed in quadruplicate). (a) Colon cancer cell lines (SW480 and HCT116 WTKo) are more sensitive to pyrvinium than a nontransformed epithelial cell line (IEC-6). (b) SW480 cells expressing full-length APC (SW480APC) are more resistant to pyrvinium than SW480 cells transfected with empty vector (SW480vector). (c) Effects of pyrvinium versus IWR-1 on viability of colon cancer cells grown under low serum conditions. Colon cancer lines were treated for 72 h with the indicated concentrations of pyrvinium pamoate or IWR-1 in media with low serum (1% (v/v) FBS) and cell viability determined.