Table 1.
Physiologic data a,b
| VH | BIL | CsA | Bil + CsA | |
|---|---|---|---|---|
| N |
5 |
5 |
5 |
5 |
| Body weight (g) |
356.5 ± 29.0 |
356.1 ± 57.6 |
318.3 ± 57.6 |
290.6 ± 10.11 |
| SBP (mmHg) |
127.5 ± 14.0 |
139.8 ± 10.0 |
149.0 ± 19.8 |
134.0 ± 15.9 |
| Serum creatinine (mg/dL) |
0.7 ± 0.1 |
0.7 ± 0.2 |
1.7 ± 0.9*† |
1.7 ± 0.3*† |
| 24 hr urine albumin (mg) |
5.4 ± 4.1 |
4.8 ± 5.1 |
9.1 ± 6.5 |
6.6 ± 3.0 |
| Serum CsA (μg/mL) |
0.02 ± 0.00 |
0.02 ± 0.00 |
2.89 ± 0.29*† |
3.31 ± 0.40*† |
| Serum LDH (IU/L) |
486.6 ± 183.8 |
623.4 ± 400.1 |
748.2 ± 182.6 |
642.2 ± 193.6 |
| Serum AST (IU/L) |
79.7 ± 18.9 |
86.2 ± 41.1 |
61.6 ± 6.1 |
66.0 ± 7.0 |
| Serum ALT (IU/L) |
29.3 ± 3.8 |
34.0 ± 17.4 |
26.4 ± 3.6 |
31.0 ± 3.3 |
| Serum bilirubin (mg/dL) | 0.03 ± 0.03 | 0.01 ± 0.02 | 0.16 ± 0.04*† | 00.20 ± 0.06*† |
aVehicle (VH): The rats received a subcutaneous (SC) injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of DMSO; Bilirubin (BIL): The rats received a SC injection of olive oil 1 ml/kg/day plus a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; cyclosporine (CsA): The rats received a SC injection of CsA 15 mg/kg/day plus a intraperitoneal injection of DMSO; BIL + CsA: The rats received a SC injection of CsA 15 mg/kg/day plus a a intraperitoneal injection of bilirubin (60 mg/kg) dissolved with DMSO; SBP, systolic blood pressure, LDH, lactate dehydrogenase.
bData are displayed as means ± SD.
*P < 0.05 vs. VH, †P < 0.05 vs. Bil, and ‡P < 0.05 vs. CsA.