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. 2013 Jun 13;9(6):e1003531. doi: 10.1371/journal.pgen.1003531

Figure 5. Interaction between vimentin over-expression and the activation of EMT signaling pathway.

Figure 5

(A) Over-expression of vimentin in G361 cells. (B) Forced expression of vimentin drives human breast tumor epithelial cells (MCF7) to a mesenchymal phenotype through the integrin-linked-kinase/GSK-3β axis. 5 mM LiCl was used to inhibit GSK-3β, as detected by the accumulation of beta-catenin. (C) ILK was knocked down to analyze the significance of the interaction between vimentin and ILK in promoting the transition to a mesenchymal phenotype.