Figure 8. PARP inhibitors interfere with EndoMT, EMT and vasculogenic mimicry in melanoma cells.

Vimentin down-regulation is pivotal in driving this effect of PARP inhibitors, acting through the ILK/GSk-3β (see the text). While VE-cadherin is upregulated by PARP inhibitors in endothelial cells, contributing to vascular normalisation, its levels are down-regulated in malignant melanoma cells (Figure 5C). The ultimate reason for this cell-specific regulation of VE-cadherin expression by PARP is being studying currently in our laboratory.