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. 2013 Jun 15;24(12):1895–1903. doi: 10.1091/mbc.E12-09-0648

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© 2013 Haunhorst et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Zebrafish Grx3 function in iron homeostasis is independent of IRP1. (A) Detection of ALAS2 levels in wild-type embryos and embryos depleted for Grx3. Diaminofluorene staining of hemoglobin at 48 hpf in (B) wild-type embryos (n = 30), (C) embryos depleted for IRP1 (n = 95), (D) embryos depleted for both IRP1 and zfGrx3 (n = 40), and (E) embryos depleted for IRP1 and overexpressing zfGrx3 by injection of zfGrx3 mRNA (n = 39). Knockdown of IRP1 and zfGrx3 was induced by injection of specific morpholinos into single-cell eggs. (F) Quantification of the experiments in B–E relative to wild-type fish.