Table 2. Clinical histories of the individual patients from the Streptococcus pneumoniae meningitis histology group.

Case Number	Age, sex	Immediate cause of death	Interval between onset of symptoms and death (days)	Other neuropathological abnormalities
1	56, f	Shock	12	Severe brain edema, herniation, necrosis of cortical and cerebellar neurons
2	81, f	Respiratory arrest	8	Moderate brain edema
3	61, f	Pulmonary embolia	6	Severe brain edema, herniation, diffuse neuronal necrosis neurons
4	63, f	Shock	91	Cortical microabscesses and focal necroses, watershed infarctions
5	57, m	Shock	6	Severe brain edema, hypoxic brain injury
6	54, m	Brain death	1	Brain edema, herniation

Note: the synaptic/cell death analysis in our tissue samples involved non-necrotic tissue areas.