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. 2013 Jun 13;8(6):e66546. doi: 10.1371/journal.pone.0066546

Figure 1. IDO increases morbidity and slows recovery in PR8-infected mice.

Figure 1

B6 (WT) or IDO1-KO mice were infected with PR8 virus (50 PFU, i/n). AB. Tissue kynurenine (Kyn) in lung homogenates (A) and IDO enzyme activity in msLN homogenates (B) were estimated by HPLC. CD. Morbidity was assessed by monitoring weight loss after infection (normalized to initial weights) in BALB/c (WT), IDO1-KO (C) and BALB/c (WT) mice given oral D1MT during infection (D). EF. Lung weights (E) and lung virus loads (F) were also evaluated. Data are the means (+/−1sd) of >3 mice/group from at least two independent experiments unless otherwise stated in the figure. **p<0.01, ****p<0.0001.