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. 2013 Jun 13;8(6):e66122. doi: 10.1371/journal.pone.0066122

Figure 3. NE-evoked and α1 adrenoceptor-mediated persistent activity depends on mGluR5 activation.

Figure 3

(A) and (B) NE- and the selective α1 adrenoceptor agonist phenylephrine (PE)-induced persistent firing were both blocked by the selective mGluR5 receptor antagonist MPEP (50 µM, n = 6 and n = 5, respectively). (C) Quantitative results of the frequency and the amplitude of plateau potentials from neurons exemplified in A and B. Values are mean ± SEM. ** p<0.01. (D) MPEP failed to block CCh-induced persistent firing (n = 4).