Table 3. Observed (Obs) and expected (Exp) cases of de-novo tumors, Standardized Incidence Ratios (SIR), and 95% Confidence Intervals (95% CI) among 494 adult recipients who underwent primary liver transplantation, 1983–2009, by years since liver transplant.

	<2 years				2–9 years				≥10 years
Cancer site/type(ICD-10 code)	Obs	Exp	SIR	95% CI	Obs	Exp	SIR	95% CI	Obs	Exp	SIR	95% CI
All cancers but skin (C00–C43, C44–C97)	11	4.1	2.7	1.3–4.8	19	12.4	1.5	0.9–2.4	11	6.5	1.7	0.8–3.0
Upper aerodigestive (C00–C14, C30–C33)	0	0.3	–	–	4	0.6	6.2	1.7–16.1	0	0.3	–	–
Stomach (C16)	1	0.2	6.3	0.2–35.0	0	0.5	–	–	0	0.2	–	–
Colon (C18)	2	0.3	6.1	0.7–21.9	0	1.0	–	–	1	0.6	1.8	0.1–10.1
Lung (C33–C34)	1	0.5	1.9	0.05–10.6	4	1.5	2.6	0.7–6.7	1	0.8	1.2	0.03–7.0
Kaposi’s sarcoma (C46)	5	0.01	393.3	127.7–917.9	2	0.03	65.5	7.9–236.6	0	0.01	–	–
Breast (C50)	0	0.5	–	–	2	1.6	1.2	0.1–4.5	1	0.9	1.1	0.03–6.3
Vulva (C51.9)*	–	–	–	–	1	–	–	–	–	–	–	–
Uterus, cervix (C53)	0	0.03	–	–	0	0.1	–	–	1	0.05	22.2	0.5–123.8
Prostate (C61)	0	0.4	–	–	4	1.3	3.0	0.8–7.8	0	0.8	–	–
Bladder (C67)	0	0.3	–	–	0	0.9	–	–	5	0.5	10.6	3.4–24.7
Central nervous system (C69–C72)	1	0.1	12.3	0.3–68.4	0	0.2	–	–	0	0.1	–	–
Hematologic cancers (C81–C96)	1	0.3	3.0	0.1–16.7	2	0.9	2.1	0.3–7.7	2	0.5	4.3	0.5–15.7
Lymphomas (C81–C85, C96)	1	0.2	5.2	0.1–28.7	2	0.5	3.7	0.5–13.5	1	0.3	4.0	0.1–22.2
Non-Hodgkin’s lymphoma (C82–C85, C96)	1	0.2	6.0	0.2–33.7	1	0.5	2.1	0.05–12.0	1	0.2	4.4	0.1–24.7
Hodgkin’s disease (C81)	0	0.03	–	–	1	0.07	14.5	0.3–80.9	0	0.03	–	–
Leukemia (C91–C95)	0	0.1	–	–	0	0.2	–	–	1	0.1	8.3	0.2–46.0

Reference: pool of Italian cancer registries.