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Severe Toxicities
| Toxicity | Grade1 | Number2 | Dose Level3 |
|---|---|---|---|
| Neutropenia | 3 | 2 | 3, 4 |
| Anemia | 3 | 1 | 5 |
| Thrombocytopenia | 3, 4 | 2 | 4, 4 |
| Hypokalemia | 3 | 2 | 3, 5 |
| Hypophosphatemia | 3 | 3 | 4, 5, 5 |
| Hypocalcemia | 3 | 1 | 4 |
| Elevated transaminases | 3 | 2 | 4, 4 |
| Hyperlipidemia | 3 | 1 | 5 |
| Stomatitis | 3 | 1 | 4 |
| Anorexia | 4 | 1 | 5 |
| Pancreatitis | 3 | 1 | 4 |
Maximum CTCAE v3.0 grade of each toxicity
The cumulative number of patients with grade 3 or higher toxicity in thefirst two cycles
Dose levels at which severe toxicitieswere observed.
