Table 2.
Segregation analysis of pedigrees with repeat expansions
| Affected with AD | Unaffected | ||||
|---|---|---|---|---|---|
| C9ORF72 repeat expansion | + | − | + | − | |
| Overall | # of Individuals | 10 | 1 | 0 | 8 |
| Mean Age ± SDa | 65.3 ± 4.9 | 65 | 60 | 69.2 ± 11.3 | |
| Age range | 60–73 | 55–79 | |||
| Family 1 | # of Individuals | 1 | 0 | 0 | 0 |
| Ages | 73 | - | - | - | |
| Family 2 | # of Individuals | 2 | 0 | 0 | 1 |
| Ages | 65,68 | - | - | 78 | |
| Family 3 | # of Individuals | 2 | 1 | 0 | 1 |
| Ages | 60 | 65 | - | 72 | |
| Family 4 | # of Individuals | 3 | 0 | 0 | 5 |
| Ages | 60,60,70 | - | - | 55–79 | |
| Family 5 | # of Individuals | 2 | 0 | 0 | 1 |
| Ages | 67,70 | - | - | 72 | |
a
For AD patients, age refers to age at symptom onset, while for unaffected individuals it refers to the age at last assessment.