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. 2013 Jun 13;8(6):e65979. doi: 10.1371/journal.pone.0065979

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© 2013 Bourgine et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Femur length of 15- and 30-day-old PiT1 ^+/+ and PiT1 ^neo/neo mice. At 15 days of age, there is a significant difference between the femur length of PiT1 ^+/+ (n = 11) and PiT1 ^neo/neo (n = 10) mice. This difference persists at 30 days of age (PiT1 ^+/+: n = 18; PiT1 ^neo/neo: n = 19). (B) Essential histomorphometric parameters to describe trabecular bone morphometry in 15- and 30-day-old PiT1 ^+/+ and PiT1 ^neo/neo femurs: the bone volume fraction (BV/TV), the trabecular number (Tb.N), the trabecular thickness (Tb.Th) and the trabecular separation (Tb. Sp). Data are represented as mean ± SEM. The analysis was repeated in 8 to 21 male and female mice in each group. Statistical analysis was carried out by Mann & Whitney’s method.