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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Transfusion. 2013 Mar 5;53(11 0 2):10.1111/trf.12145. doi: 10.1111/trf.12145

Figure 2.

Figure 2

Phylogeny of DIV. The phylogenetic tree is based on a previous tree for RHD29,39 with 4 main branches representing allele clusters. The three African D clusters have characteristic primordial amino acids and typically occur in a cDe haplotype while the Eurasian D cluster has normal RHD as the primordial structure in which the Ce and cE alleles of RHCE evolved. The DIVa cluster is one of the 3 African D clusters; D variants of this cluster share the ancestral amino acid substitutions 62F, 137V and152T relative to the consensus RhD. In contrast, DIV variants with DIVb phenotype evolved in the Eurasian D cluster by gene conversions. The typically associated RHCE alleles are shown.