Table 2.

Geometric means of biomarkers at baseline and week 6 of treatment period by treatment groups. Values are for all subjects from whom data were collected at the visit in question.

Biomarkers		Baseline		Week 6
	N	Geometric Mean (95% CI)	N	Geometric Mean (95% CI)
Total TNE 1
VLNC Cigarette	54	55.70 (48.42, 64.07)	54	6.89 (4.26, 11.02)
Patch	59	49.90 (43.82, 57.40)	58	23.10 (14.59, 36.60)
VLNC Cigarette + Patch	58	53.52 (46.99, 61.56)	58	27.39 (17.29, 43.38)
Total Cotinine 1
VLNC Cigarette	54	17.12 (14.44, 20.09)	54	2.03 (1.20, 3.45)
Patch	59	16.78 (14.30, 19.69)	59	5.50 (3.31, 9.13)
VLNC Cigarette + Patch	58	17.99 (15.33, 21.12)	58	7.65 (4.59, 12.76)
Total NNAL 2
VLNC Cigarette	53	1.20 (1.00, 1.43)	52	0.40 (0.29, 0.55)
Patch	59	1.29 (1.09, 1.53)	59	0.25 (0.18, 0.34)
VLNC Cigarette + Patch	57	1.09 (0.92, 1.30)	55	0.26 (0.19, 0.36)

¹nmol/mg creatinine

²pmol/mg creatinine