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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Chem Rev. 2012 Oct 11;112(12):6388–6430. doi: 10.1021/cr300141q

Figure 14.

Figure 14

Sequence of events showing BoNT light chain translocation through the heavy chain channel. Step1. BoNT/A holotoxin prior to insertion in the membrane (grey bar with magenta boundaries); BoNT/A is represented by the crystal structure rendered on YASARA using PDB accession code 3BTA351. Step 2. Schematic representation of the membrane inserted BoNT/A during an entry event. Steps 3 and 4. A series of transfer steps. Step 5. An exit event. Segments of typical single channel recordings are displayed under the corresponding interpretation for each step. Reprinted with permission from ref282. Copyright 2009. Elsevier.