Figure 5. BIBF 1120 does not drive an invasive phenotype in lung cancer.
EMT markers from lung tumors were evaluated by immunohistochemistry. A) Representative images of mature myofibroblasts (α-SMA) at 200x magnification with DAPI labeling nuclei. B) Representative images of E-cadherin and vimentin at 200x magnification. C) Quantification of fibroblasts, E-cadherin and vimentin. Bar graphs indicate mean +/− SEM. A minimum of 5 images were acquired per group. Results were given as mean percentage of thresholded area per field. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001 by Dunn’s post-test.