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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Clin Gastroenterol. 2013 Jul;47(6):553–558. doi: 10.1097/MCG.0b013e318276bf00

Table 3. Selected laboratory data at and following DILI onset (N=32, presented as mean± s.d).

N=32
At protocol defined date of onset:
 - ALT (U/L) 499 ± 585
 - AST (U/L) 414 ± 499
 - AlkP (U/L) 365 ± 345
 - Total Bilirubin (mg/Dl) 4.8 ± 6.5
 - INR 1.1 ± 0.2
Pattern of Liver Injury
 - Cholestatic 11/30 (36.7%)
 - Mixed 10/30 (33.3%)
 - Hepatocellular 9/30 (30.0%)
Peak values:
 - ALT (U/L) 686 ± 915
 - AST (U/L) 491 ± 488
 - AlkP (U/L) 623 ± 563
 - Total Bilirubin (mg/dL) 8.7 ± 10.3
 - INR 1.4 ± 0.6
Times to Peak and Recovery (in days)
ALT:
 - Onset to Peak 11 ± 26
 - Peak to 50% Reduction 25± 37
 - Peak to below ULN 106 ± 152
AST:
 - Onset to Peak 4 ± 6
 - Peak to a 50% Reduction from Peak 8 ± 13
 - Peak to below ULN 101 ± 163
AlkP:
 - Onset to Peak 31 ± 45
 - Peak to a 50% Reduction from Peak 56 ± 69
 - Peak to below ULN 123 ± 195
Total Bilirubin:
 - Onset to Peak 40 ± 88
 - Peak to a 50% Reduction from Peak 20 ± 28
 - Peak to < 2.5 mg/dL 41 ± 44
Eosinophils *
 - Absolute eosinophil (count/μL) 286 ± 407
 - Eosinophil > 500/μL 4/17 (23.5%)
*

Only 17 patients had a complete blood count within 2 weeks of onset to calculate eosinophil counts.

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AlkP: Alkaline Phosphatase; INR: International Normalized Ratio; ULN: Upper limit of normal