Table 2. Univariate analysis of clinicopathological variables and S100P protein expression with early tumor recurrence (ETR) in patients with surgical removed unifocal primary hepatocellular carcinoma.
| ETR | ||||
| Variables | Total | Yes n (%) | Odds Ratio | P value |
| Clinical features | ||||
| Age | ||||
| >56 | 114 | 41 (43) | 1.0 | |
| ≤56 | 145 | 70 (48) | 1.24 (0.73–2.09) | 0.3961 |
| Sex | ||||
| Male | 201 | 85 (42) | 1.0 | |
| Female | 58 | 26 (45) | 1.11 (0.59–2.08) | 0.7307 |
| HBsAg | ||||
| Negative | 88 | 27 (31) | 1.0 | |
| Positive | 171 | 84 (49) | 2.18 (1.22–3.90) | 0.0045 |
| Anti-HCV | ||||
| Negative | 163 | 74 (45) | 1.0 | |
| Positive | 80 | 30 (38) | 1.39 (0.77–2.49) | 0.2422 |
| Histopathological features | ||||
| Tumor size (cm) | ||||
| ≤5 | 130 | 34 (26) | 1.0 | |
| >5 | 129 | 77 (60) | 4.18 (2.47–7.07) | 1.2×10−6 |
| Tumor grade | ||||
| 1 | 176 | 68 (38) | 1.0 | |
| 2∼4 | 83 | 43 (52) | 1.70 (1.01–2.89) | 0.0456 |
| Tumor stage | ||||
| I | 114 | 19 (17) | 1.0 | |
| II∼III | 145 | 92 (63) | 8.68 (4.78–15.77) | <1×10−7 |
| Molecular markers | ||||
| α-fetoprotein (ng/ml) | ||||
| ≤200 | 144 | 43 (30) | 1.0 | |
| >200 | 115 | 68 (59) | 3.40 (1.97–5.89) | 2.3×10−6 |
| p53 mutation | ||||
| No | 89 | 30 (34) | 1.0 | |
| Yes | 74 | 42 (57) | 2.58 (1.30–5.14) | 0.0032 |
| β-Catenin mutation | ||||
| No | 158 | 79 (50) | 1.0 | |
| Yes | 26 | 4 (15) | 5.50 (1.81–16.69) | 0.0011 |
| S100P expression | ||||
| No | 115 | 40 (35) | 1.0 | |
| Yes | 144 | 71 (49) | 1.82 (1.07–3.12) | 0.0189 |