Table 2.
Enriched regulatory cis-elements in the promoters of Hsp70 superfamily genes
| Regulatory cis-elements | Number of promoters | Predicted sites in promoters | p value | Genes |
|---|---|---|---|---|
| HSE-perfect type | 5 | 5 | 10−4 | cHsp70-1, cHsp70-2, cHsp70-4, cHsp70-7, and mtHsp70-1 |
| Nonenriched TFBS | ||||
| ABREmotif | 12 | 18 | 0.0136 | cHsp70-1, cHsp70-8, cHsp70-10, BiP-1, BiP-4, mtHsp70-1, cpHsp70-1, cpHsp70-2, Hsp110-1, Hsp110-2, Hsp110-5, and Hsp110-8 |
| DRECRTCOREAT | 14 | 19 | 0.034 | cHsp70-1, cHsp70-2, cHsp70-3, cHsp70-4, cHsp70-5, cHsp70-6, cHsp70-7, cHsp70-8, cHsp70-10, BiP-4, mtHsp70-3, cpHsp70-2, uHsp70-2, and Hsp110-5 |
| HSE gaptype | 2 | 2 | 0.0205 | cHsp70-6 and cHsp70-10 |
| HSE steptype | 1 | 1 | 0.485 | cHsp70-2 |
| SITEIIATCYTC | 21 | 64 | 0.0069 | cHsp70-1 cHsp70-2 cHsp70-3, cHsp70-4, cHsp70-5, cHsp70-6, cHsp70-7, cHsp70-8, cHsp70-10, BiP-1, BiP-4, mtHsp70-1, mtHsp70-2, mtHsp70-3, cpHsp70-2, uHsp70-1, Hsp110-1, Hsp110-3, Hsp110-4, Hsp110-5, and Hsp110-8 |
| MotifI | 3 | 3 | 0.0175 | cHsp70-5, Hsp110-6, and Hsp110-7 |
| Imperfect HSE | cHsp70-3, cHsp70-5, cHsp70-6, cHsp70-10, BiP-2, BiP-3, BiP-5, mtHsp70-3, and cpHsp70-1 | |||
p values represent statistically over-represented TF binding sites in selected set of promoters
HSE-perfect type nTTCnnGAAnnTTCn, HSE-gaptype nTTCnnGAAnnnnnnnTTCn, HSE steptype nTTCnnnnnnnTTCnnnnnnnTTCn, ABRE-motif TGACGT, DRE/CRT motif RCCGAC, SiteII element TGGGCY, MotifI RTACGTGGR