Table 2.
Levels of HSP70 (HSPA1A) and of other biomarkers measured 24 h after the initiation of therapeutic hypothermia in post-cardiac-arrest patients (all patients, and subsets created according to 30-day survival)
| Parameters | All patients (n = 46) | Survivors (n = 24) | Non-survivors (n = 22) | p valuea |
|---|---|---|---|---|
| HSP70 (ng/ml) | 0.74 (0.33–1.66)b | 0.56 (0.16–0.71) | 1.54 (0.79–1.72) | <0.001 |
| ET (fmol/ml) | 1.58 (1.16–2.63) | 1.23 (0.99–1.67) | 2.35 (1.49–3.07) | 0.0011 |
| vWF (μg/ml) | 664.6 (477.7–859.3) | 624.3 (433.4–804.6) | 768.0 (557.7–1159.7) | 0.0411 |
| sICAM-1 (ng/ml) | 311.8 (221.1–368.1) | 292.5 (211.3–332.7) | 368.1 (227.6–444.8) | 0.1511 |
| CRP (μg/ml) | 87.0 (49.7–129.4) | 77.0 (36.9–87.0) | 126.0 (95.9–141.9) | 0.0018 |
| TNF-alpha (pg/ml) | 4.73 (2.11–7.62) | 3.80 (1.50–5.23) | 5.93 (4.66–7.62) | 0.0205 |
| S100B (pg/ml) | 3.7 (1.1–216.5) | 2.7 (1.1–75.5) | 8.5 (1.1–420.1) | 0.1441 |
ET Big Endothelin, vWF von Willebrand factor, sICAM-1 soluble intercellular adhesion molecule, CRP acute-phase protein C-reactive protein, TNF-alpha pro-inflammatory cytokine tumor necrosis factor-alpha, S100B the marker of brain damage, S100 protein B
aMann–Whitney test between survivors and non-survivors
bMedian values and interquartile ranges