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Mechanical testing and TRAP assay in wild-type and TTD mice. Polar moment of inertia in tibiae (a), ultimate load applied on femurs (b), serum TRAP levels (c), of wild-type (solid symbols) and TTD (open symbols) mice. TTD mice compared to wild-type animals: # p < 0.05, ### p < 0.001; TTD and wild-type mice compared to their 26-week time point: *p < 0.05, ***p < 0.001; error bars represent SEM
