Table 3.
Histological characteristics of soleus and EDL muscles of Zmpste24+/+ and Zmpste24−/− mice
| Zmpste24+/+ | Zmpste24−/− | p value | |
|---|---|---|---|
| Soleus muscle (n) | (5) | (5) | |
| % Type I | 38.3 ± 2.6 | 33.7 ± 2.1 | 0.203 |
| % Type IIa | 59.3 ± 3.0 | 63.4 ± 2.0 | 0.277 |
| % Type IIx | 2.2 ± 0.6 | 3.1 ± 1.4 | 0.559 |
| Capillaries per fiber | 3.3 ± 0.1 | 3.4 ± 0.1 | 0.775 |
| % Central nuclei | 0.72 ± 0.4 | 0.76 ± 0.5 | 0.961 |
| Myonuclei per fiber | 2.7 ± 0.2 | 3.3 ± 0.2 | 0.023 |
| Extracellular nuclei per area (mm2) | 2.1 ± 0.5 | 2.1 ± 0.4 | 0.889 |
| EDL muscle (n) | (4) | (5) | |
| % Type I | 2.0 ± 0.5 | 4.1 ± 0.8 | 0.079 |
| % Type IIa | 12.3 ± 1.8 | 22.2 ± 1.8 | 0.007 |
| % Type IIx | 23.0 ± 2.2 | 25.8 ± 2.8 | 0.467 |
| % Type IIb | 62.5 ± 3.3 | 48.0 ± 2.9 | 0.013 |
| Capillaries per fiber | 2.2 ± 0.3 | 2.2 ± 0.2 | 0.683 |
| % Central nuclei | 1.3 ± 0.2 | 2.3 ± 0.4 | 0.078 |
| Myonuclei per fiber | 1.9 ± 0.2 | 2.4 ± 0.1 | 0.004 |
| Extracellular nuclei per area (mm2) | 4.7 ± 2.1 | 6.2 ± 3.2 | 0.511 |
Mean ± SE. Fiber types based on myosin heavy chain immunohistochemistry and expressed as percentages of total number of fibers. No soleus muscle fibers expressed myosin heavy chain IIb.% Central nuclei, percent of fibers that had central nuclei