Fig. 3.
Cell proliferation curves of human diploid fibroblasts exposed to 250 or 500 μM of copper sulfate. Both BME and control cells presented approximately the same proliferation rate during the 4 days after stress. At the fourth day after treatment, cells exposed to 250 or 500 μM CuSO4 showed a decrease in cell proliferation of about 58% and 79%, respectively, when compared with control cells. Data are expressed as mean ± SEM from three independent experiments. *p < 0.05 when compared with the same time-point of the control