An illustration of automated atlas based tissue segmentation of a 3D T2W fetal brain MRI using an age specific prior map of tissue probability, MRI contrast and brain shape and size. Labels assigned to each voxel dividing the brain into Cortical Plate, Intermediate Zone and Sub-Plate, Deep Grey Matter, Germinal Matrix and Ventricular CSF, are adapted from the atlas prior to fit the subject MRI scan using an iterative Expectation Maximization algorithm (132).