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Physiological mechanisms of tACS. Left: In vivo recordings in ferrets show that spontaneous neuronal activity seen in MUA synchronizes to certain phases of LFPs. Right: Stimulating slices of cortex electrically with sinusoidal currents results in a similar synchronization. Interestingly, the inter-burst frequency of the spontaneously occurring activity can be speeded up and slowed down resulting in neural entrainment [adapted from Fröhlich and McCormick (2010)].
