Figure 7.

Effects of diazepam and osemozotan (a), and LY379268 (b)on encounter-induced increases in DA and 5-HT levels in the prefrontal cortex of male isolation-reared mice. A male isolation-reared mouse was placed into the large compartment of a novel clear Plexiglas cage divided by a mesh partition. After a 3-h habituation period, the resident mice were intraperitoneally injected with vehicle, diazepam (1 mg/kg), or osemozotan (0.3 mg/kg) 30 min before the encounter (a) and were intraperitoneally injected with saline or LY379268 (1 mg/kg) 60 min before the encounter (b) (arrow). After the drug treatment, an unfamiliar male intruder was placed into the unoccupied compartment and the mice were allowed to interact for 20 min, as indicated by the horizontal bar. The data are expressed as the mean±SEM of 10 mice/group.