Table 2. Mean Peak Effects During Marijuana Administration (5.6% THC) and During Marijuana Abstinence (0.0%) as a Function of Nabilone Dose.

Marijuana strength	5.6%	0.0%	0.0%	0.0%
Nabilone dose (mg/day)	0	0	6	8
Anxious cluster	18.8 (7.1)	↑27.2 (7.0)#	22.6 (6.2)	24.2 (6.0)
Bad effect cluster	7.2 (3.7)	↑14.1 (5.4)#	↓10.4 (4.8)*	11.0 (3.3)
Social cluster	67.7 (6.9)	↓58.7 (5.4)#	54.9 (4.4)	↓53.6 (4.9)*
Marijuana craving	78.0 (9.2)	↓60.1 (8.6)#	↓44.9 (9.4)**	↓48.3 (9.9)*
Hungry	66.4 (10.4)	↓36.1 (7.7) ##	44.4 (9.7)	47.0 (10.2)
Fell asleep easily	69.3 (11.1)	49.0 (9.2)	↑62.2 (8.3)*	↑77.7 (6.5)**
Sleep satisfaction	71.1 (9.1)	51.0 (8.7)	63.8 (8.5)	↑68.4 (7.1)*
Cholesterol (%)	57.9 (2.1)	↑62.1 (1.7) #	59.7 (1.5)	↓57.7 (1.6)*
Fat (%)	32.3 (2.1)	↓27.4 (1.4)##	↑30.9 (1.6)*	↑33.2 (1.8)**
Protein (%)	9.8 (0.6)	10.6 (0.6)	↓9.4 (0.3)*	↓9.1 (0.4)**
DSST (# entered)	76.6 (5.2)	↑85.4 (3.2)#	83.0 (3.7)	↓77.8 (3.7)**
RAT (# entered)	23.3 (4.1)	25.7 (5.6)	24.2 (5.3)	↓21.0 (4.6)*
Systolic pressure	115.6 (1.6)	↑119.7 (1.2)#	↓113.7 (1.8)**	↓114.5 (1.9)**
Diastolic pressure	69.3 (1.6)	↑73.7 (1.2)#	↓67.7 (1.5)**	↓66.6 (1.5)**
Heart rate	63.0 (2.6)	↑67.2 (2.0)#	66.4 (2.1)	66.4 (2.1)

Abbreviations: DSST, digit symbol substitution task; RAT, repeated-acquisition task.

Note: Data in parentheses represent SEM; maximum mood score =100 mm. Cardiovascular data were collected while participants were seated. Asterisks represent significant differences from placebo nabilone *p<0.05, **p<0.01, and the adjacent arrow signs indicate the direction of the significant effect. Number signs represent significant differences between active marijuana administration and marijuana abstinence under placebo nabilone conditions #p<0.05, ##p<0.01, and the adjacent arrow signs indicate the direction of the significant effect.